2015;29(4):277-91. doi:10.1007/s40263-015-0239-x, Davies JT, Delfino SF, Feinberg CE, et al. The first person to synthesize Lipitor was Bruce Roth, in 1985. Lipitor is an adjunct therapy to diet and is typically prescribed in cases where lifestyle changes (diet, physical activity) or other medications are not effective in lowering cholesterol. The adverse effects of taking statins have repeatedly been under the spotlight. Simvastatin and pravastatin were more well-tolerated in the study, yet not as potent or effective at lowering cholesterol as atorvastatin or rosuvastatin. Fluvastatin and lovastatin are additional low-potency options. While you are taking Lipitor, your doctor will have you come in periodically for blood tests to monitor your cholesterol levels and to check if your dosage needs to be adjusted. Effect of high-potency statins on HbA1c in patients with or without diabetes mellitus. Gastroenterol Hepatol (N Y). All rights reserved. Borderline: 130 to 159 mg/dL. CVD includes coronary heart disease, stroke, or peripheral vascular disease. Research has found that rosuvastatin reduces LDL cholesterol by an average of 51% followed by atorvastatin at 45%, simvastatin at 37%, and pravastatin at 25%.. Up to 1 in 100 people may experience less common effects. What should I do? Statins like Lipitor are sometimes prescribed off-label to try to stop the progression of autoimmune or chronic inflammatory diseases, such as secondary progressive multiple sclerosis (SPMS).. These affect the circulation outside the heart and the brain. Last medically reviewed on February 25, 2019, Do statins increase the risk of type 2 diabetes? MNT is the registered trade mark of Healthline Media. Good: 60 mg/dL or higher. In 2016, one source described Lipitor as the “Best-selling drug of all time.”. doi:10.3138/ptc.2012-65. But if it has been more than 12 hours since the missed dose, skip it and just take your next scheduled dose. People also know it as atorvastatin. According to the CDC, in 2011–2012, nearly 28 percent of adults aged 40 years and over were using some kind of prescription drug to lower cholesterol. Your dosage of Lipitor may need to be lowered or stopped. Extended-release tablets are available as Lescol XL (fluvastatin) and Altoprev (lovastatin). What are the side effects of Lipitor? Lipitor is highly effective at treating people with a high risk of these diseases. If you are taking any of these drugs with Lipitor, your healthcare provider may need to adjust your dose, monitor you more closely for side effects, or discontinue one of the drugs:. By using Verywell Health, you accept our, Cholesterol & Triglycerides: What You Need to Know, An Overview of Drug-Induced Liver Disease, How Zocor (Simvastatin) Works to Lower Your Cholesterol, An Ace Inhibitor Used for Hypertension and Heart Failure, General Information About Livalo (Pitavastatin), Crestor: Uses, Side Effects, Dosages, Interactions, Metoprolol: Used to Treat High Blood Pressure and Angina, What to Know Before Starting a Bile Acid Resin to Lower LDL, How the Atrogin-1 Gene May Cause Muscle Pain for Statin Users, Taking Statins? Alan Carter, PharmD Answers represent the opinions of our medical experts. If you are experiencing any side effects from taking Lipitor that become prolonged or bothersome, you should let your healthcare provider know. Lipitor is its brand name. CNS Drugs. People with CVD are at risk of angina and myocardial infarction, or a heart attack. Statins lower cholesterol levels in the blood by blocking 3-hydroxy-3methylglutaryl coenzyme A (HMG CoA) reductase, an enzyme that's needed for the liver to produce cholesterol. Lipitor (atorvastatin) is a cholesterol-lowering medication that belongs to the statin class of drugs. Store the tablets at a controlled room temperature that's ideally 68 to 77 degrees F. If you miss a dose of Lipitor, take it as soon as you remember. You may also need to be monitored more closely if you have certain medical conditions that could be aggravated by taking the medication or increase the risk of side effects. Never increase your dose without your doctor's OK. As with all drugs and all statins, Lipitor comes with the risk of side effects. HDL. Patients who use Lipitor should not consume more than 1–2 small glasses of grapefruit juice in a day, because this can affect how the drug works. Common side effects of Lipitor and other statins include headache, nausea, and muscle aches that often go away as your body adjusts. Mendes P, Robles PG, Mathur S. Statin-induced rhabdomyolysis: a comprehensive review of case reports. Other statins include fluvastatin, pravastatin, rosuvastatin, and simvastatin. There are multiple types of statins and Lipitor is one of the more potent options. Statins stop the body from producing bad cholesterol by suppressing an enzyme in the liver, called HMG-CoA reductase. These changes include; not smoking, eating a healthy diet, sitting less and exercising more, and maintaining a healthy waistline of less than 40 inches for men and less than 35 inches for women. 2016;9:13-29. doi:10.4137/LPI.S37450. In this article learn about the vegan diet, the Mediterranean diet, and the TLC diet. Highlights of prescribing information: Lipitor. 2014;66(2):124–132. Lipitor may give rise to a number of side effects. High: 160 mg/dL or higher. Lipitor can cause muscle myopathy (muscle disease that causes muscle aches or weakness) and rhabdomyolysis (muscle breakdown). If you have a history of heart attacks or you're at a very high risk of a heart attack or stroke, you may need to aim even lower (below 70 mg/dL, or 1.8 mmol/L). It is also not suitable for use while breastfeeding, as it is not clear whether the drug can enter the breast milk. These can lower LDL, the “bad” cholesterol, by up to 15%. Your risk of experiencing rhabdomyolysis can increase if you are taking other medications or are older than 65.. Physiother Can. LIPITOR can be administered as a single dose at any time of the day, with or without food. 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